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Article

The Plasticity of the Hsp90 Co-chaperone System.

Molecular cell - 21 Sept 2017

Sahasrabudhe Priyanka, Rohrberg Julia, Biebl Maximillian M, Rutz Daniel A, Buchner Johannes

Abstract excerpt

The Hsp90 system in the eukaryotic cytosol is characterized by a cohort of co-chaperones that bind to Hsp90 and affect its function. Although progress has been made regarding the underlying biochemical mechanisms, how co-chaperones influence Hsp90 client proteins in vivo has remained elusive. By investigating the effect of 12 Hsp90 co-chaperones on the activity of different client proteins in yeast, we find that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28890336
DOI: 10.1016/j.molcel.2017.08.004

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