Article
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Scientific reports - 14 Jul 2015
Basarab Gregory S, Kern Gunther H, McNulty John, Mueller John P, Lawrence Kenneth, Vishwanathan Karthick, Alm Richard A, Barvian Kevin, Doig Peter, Galullo Vincent, Gardner Humphrey, Gowravaram Madhusudhan, Huband Michael, Kimzey Amy, Morningstar Marshall, Kutschke Amy, Lahiri Sushmita D, Perros Manos, Singh Renu, Schuck Virna J A, Tommasi Ruben, Walkup Grant, Newman Joseph V
Abstract excerpt
With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance. ETX0914, the first of a new class of antibacterial agent targeted for the treatment of gonorrhea, operates by a novel mode-of-inhibition against bacterial type II topoisomerases. Incorporating an oxazolidinone on the scaffold...
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