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Ultrasensitive sequencing of STR markers utilizing unique molecular identifiers and the SiMSen-Seq method.

Forensic science international. Genetics - 1 Jul 2024

Sidstedt Maja, Gynnå Arvid H, Kiesler Kevin M, Jansson Linda, Steffen Carolyn R, Håkansson Joakim, Johansson Gustav, Österlund Tobias, Bogestål Yalda, Tillmar Andreas, Rådström Peter, Ståhlberg Anders, Vallone Peter M, Hedman Johannes

Abstract excerpt

Massively parallel sequencing (MPS) is increasingly applied in forensic short tandem repeat (STR) analysis. The presence of stutter artefacts and other PCR or sequencing errors in the MPS-STR data partly limits the detection of low DNA amounts, e.g., in complex mixtures. Unique molecular identifiers (UMIs) have been applied in several scientific fields to reduce noise in sequencing. UMIs consist of a stretch of...

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PMID: 38598919
DOI: 10.1016/j.fsigen.2024.103047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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