Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases.

PLoS genetics - 1 Apr 2024

Alvarado Obando Manuela, Rey-Varela Diego, Cava Felipe, Dörr Tobias

Abstract excerpt

Peptidoglycan (PG) is the main component of the bacterial cell wall; it maintains cell shape while protecting the cell from internal osmotic pressure and external environmental challenges. PG synthesis is essential for bacterial growth and survival, and a series of PG modifications are required to allow expansion of the sacculus. Endopeptidases (EPs), for example, cleave the crosslinks between adjacent PG strands...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Carboxypeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Wall

Share to Endopeptidases

Share to Epistasis, Genetic

Share to Gene Expression Regulation, Bacterial

Share to Peptidoglycan

Share to Vibrio cholerae

Source

Open in PubMed Open full text

Identifiers

PMID: 38598601
DOI: 10.1371/journal.pgen.1011234
PMCID: PMC11034669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases.PMID 38598601Read ↗

Structural basis of peptidoglycan endopeptidase regulation.Semantic proximity Read ↗

Functional profiling of CHAP domain-containing peptidoglycan hydrolases of Staphylococcus aureus USA300 uncovers potential targets for anti-staphylococcal therapiesSemantic proximity Read ↗

Characterization of mutants deficient in the L,D-carboxypeptidase (DacB) and WalRK (VicRK) regulon, involved in peptidoglycan maturation of Streptococcus pneumoniae serotype 2 strain D39.Semantic proximity Read ↗

Identification of Three New GGDEF and EAL Domain-Containing Proteins Participating in the Scr Surface Colonization Regulatory Network in Vibrio parahaemolyticus.Semantic proximity Read ↗

Endopeptidase regulation as a novel function of the Zur-dependent zinc starvation responseSemantic proximity Read ↗

Divergent LD-transpeptidase-independent effects of peptidoglycan carboxypeptidases on intrinsic β-lactam and vancomycin resistanceSemantic proximity Read ↗

Identification and functional characterization of the putative polysaccharide biosynthesis protein (CapD) of Enterococcus faecium U0317.Semantic proximity Read ↗

Specialized peptidoglycan hydrolases sculpt the intra-bacterial niche of predatory Bdellovibrio and increase population fitness.Semantic proximity Read ↗

The active repertoire of <i>Escherichia coli</i> peptidoglycan amidases varies with physiochemical environmentSemantic proximity Read ↗

Lysis of a Lactococcus lactis Dipeptidase Mutant and Rescue by Mutation in the Pleiotropic Regulator CodY.Semantic proximity Read ↗

Identification of an essential gene responsible for D-Asp incorporation in the Lactococcus lactis peptidoglycan crossbridge.Semantic proximity Read ↗

Elucidating the CodY regulon in Staphylococcus aureus USA300 substrains TCH1516 and LACSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.