Article
Specialized peptidoglycan hydrolases sculpt the intra-bacterial niche of predatory Bdellovibrio and increase population fitness.
PLoS pathogens - 1 Feb 2012
Lerner Thomas R, Lovering Andrew L, Bui Nhat Khai, Uchida Kaoru, Aizawa Shin-ichi, Vollmer Waldemar, Sockett R Elizabeth
Abstract excerpt
Bdellovibrio are predatory bacteria that have evolved to invade virtually all gram-negative bacteria, including many prominent pathogens. Upon invasion, prey bacteria become rounded up into an osmotically stable niche for the Bdellovibrio, preventing further superinfection and allowing Bdellovibrio to replicate inside without competition, killing the prey bacterium and degrading its contents. Historically, prey...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Bdellovibrio
- Catalytic Domain
- Crystallization
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Genetic Fitness
- Models, Molecular
- Molecular Sequence Data
- Mutation
- N-Acetylmuramoyl-L-alanine Amidase