Article
N-glycoproteomic analyses of human intestinal enteroids, varying in histo-blood group geno- and phenotypes, reveal a wide repertoire of fucosylated glycoproteins.
Glycobiology - 24 Apr 2024
Nilsson Jonas, Rimkute Inga, Sihlbom Carina, Tenge Victoria R, Lin Shih-Ching, Atmar Robert L, Estes Mary K, Larson Göran
Abstract excerpt
Human noroviruses, globally the main cause of viral gastroenteritis, show strain specific affinity for histo-blood group antigens (HBGA) and can successfully be propagated ex vivo in human intestinal enteroids (HIEs). HIEs established from jejunal stem cells of individuals with different ABO, Lewis and secretor geno- and phenotypes, show varying susceptibility to such infections. Using bottom-up glycoproteomic...
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