Article
Causal associations of antioxidants with Alzheimer's disease and cognitive function: a Mendelian randomisation study.
Journal of epidemiology and community health - 10 Jun 2024
Wang Jiao, Huang Yingyue, Bei Chunhua, Yang Huiling, Lin Zihong, Xu Lin
Abstract excerpt
BACKGROUND: Circulating antioxidants are associated with a lower risk of Alzheimer's disease (AD) in observational studies, suggesting potential target areas for intervention. However, whether the associations are causal remains unclear. Here, we studied the causality between antioxidants and AD or cognitive function using two-sample Mendelian randomisation (MR). METHODS: Single nucleotide polymorphisms strongly...
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