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Article

TERT Promoter Mutations Increase Tumor Aggressiveness by Altering TERT mRNA Splicing in Papillary Thyroid Carcinoma.

The Journal of clinical endocrinology and metabolism - 16 Sept 2024

Sako Ayaka, Matsuse Michiko, Saenko Vladimir, Tanaka Aya, Otsubo Ryota, Morita Michi, Kuba Sayaka, Nishihara Eijun, Suzuki Keiji, Ogi Tomoo, Kawakami Atsushi, Mitsutake Norisato

Abstract excerpt

CONTEXT: Telomerase reverse transcriptase promoter (TERT-p) mutations, which upregulate TERT expression, are strongly associated with tumor aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). TERT expression is also observed in a proportion of PTCs without TERT-p mutations, but such tumors show less aggressiveness and better prognosis than TERT-p mutation-positive tumors. OBJECTIVE: TERT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Thyroid Cancer, Papillary

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Source

Identifiers

PMID: 38576411
DOI: 10.1210/clinem/dgae220

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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