Critical Role of Molecular-Based Stratification in Low-Risk Myelodysplastic Syndrome with Direct Progression to Acute Myeloid Leukemia: A Case Report.

doi:10.3390/ijms27104557

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Article

Critical Role of Molecular-Based Stratification in Low-Risk Myelodysplastic Syndrome with Direct Progression to Acute Myeloid Leukemia: A Case Report.

International journal of molecular sciences - 19 May 2026

Mihai Stejara Nicoleta, Dragu Denisa, Mambet Cristina, Botezatu Anca, Gurban Petruta, Necula Laura G, Matei Lilia, Neagu Ana Iulia, Pitica Ioana, Ataman Marius, Nedeianu Saviana, Chivu-Economescu Mihaela, Bleotu Coralia, Grosu-Ferea Catalina Roxana, Ciufu Cristina, Diaconu Carmen C, Vladareanu Ana Maria

Abstract excerpt

The genomic landscape of myelodysplastic syndromes/neoplasms (MDS), a heterogeneous group of myeloid malignancies defined by bone marrow cell dysplasia with ineffective hematopoiesis, includes somatic and, less frequently, germline mutations in hematopoietic stem and progenitor cells, along with chromosomal abnormalities. The latest World Health Organization 2022 classification of myeloid neoplasms, as well as...

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Identifiers

PMID: 42196533
DOI: 10.3390/ijms27104557
PMCID: PMC13207156

Genes

BCOR
BCORL1
RUNX1
SRSF2
TET2

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