Article
The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally.
Cell reports - 23 Apr 2024
Harris Jordan C, Trigg Natalie A, Goshu Bruktawit, Yokoyama Yuichi, Dohnalová Lenka, White Ellen K, Harman Adele, Murga-Garrido Sofía M, Ting-Chun Pan Jamie, Bhanap Preeti, Thaiss Christoph A, Grice Elizabeth A, Conine Colin C, Kambayashi Taku
Abstract excerpt
The host-microbiota relationship has evolved to shape mammalian physiology, including immunity, metabolism, and development. Germ-free models are widely used to study microbial effects on host processes such as immunity. Here, we find that both germ-free and T cell-deficient mice exhibit a robust sebum secretion defect persisting across multiple generations despite microbial colonization and T cell repletion....
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