Article

Embryonic Signatures of Intergenerational Inheritance across Paternal Environments and Genetic Backgrounds

2024-11-26

Abstract excerpt

The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F 1 offspring. However, the prevalence and mechanisms of such intergenerational epigenetic inheritance (IEI) in mammals remain poorly defined. Moreover, the interplay between paternal exposure, genetics, and age on emergent offspring features is unexplored. Here, we measure the quantitative impact of...

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Literature Corpus work: 822d512b-13ea-554c-891d-294087c1ffd3
DOI: 10.1101/2024.11.25.624914

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