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Article

Investigation of Paclitaxel Resistant R306C Mutation in β-Tubulin—A Computational Approach.

Journal of cellular biochemistry - 1 Jul 2015

Verma Kanika, Ramanathan K

Abstract excerpt

Paclitaxel is the most effective chemotherapeutic agent used for the treatment of a broad spectrum of solid tumors. However, observed paclitaxel resistance in clinical trials presents one of the major obstacles for cancer chemotherapy. Most importantly, resistance due to β-tubulin mutations (R306C) has been intensely debated in recent years. Despite all efforts, mechanism of resistance is still not well...

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Identifiers

PMID: 25735511
DOI: 10.1002/jcb.25087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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