Article
Juxta-articular joint-capsule mineralization in CD73 deficient mice: similarities to patients with NT5E mutations.
Cell cycle (Georgetown, Tex.) - 1 Jan 2014
Li Qiaoli, Price Thea P, Sundberg John P, Uitto Jouni
Abstract excerpt
Arterial calcification due to CD73 deficiency (ACDC), an autosomal recessive disorder, manifests with extensive mineralization of the lower-extremity arteries as well as of hand and foot joint-capsules. This disease is caused by mutations in the NT5E gene which encodes CD73, a membrane-bound ecto-5'-nucleotidase hydrolyzing 5'-AMP into adenosine and Pi. To gain insight into the pathophysiologic details of ACDC,...
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