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Article

The mTORC2 Component Rictor Contributes to Cisplatin Resistance in Human Ovarian Cancer Cells

23 Sept 2013

Abstract excerpt

Resistance to cisplatin-based therapy is a major cause of treatment failure in human ovarian cancer. A better understanding of the mechanisms of cisplatin resistance will offer new insights for novel therapeutic strategies for this deadly disease. Akt and p53 are determinants of cisplatin sensitivity. Rictor is a component of mTOR protein kinase complex 2, which is required for Akt phosphorylation (Ser473) and...

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PMID: 24086535
DOI: 10.1371/journal.pone.0075455

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