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Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy

24 Jan 2024

Abstract excerpt

To solve the clinical transformation dilemma of lamin A/C (LMNA)-mutated dilated cardiomyopathy (LMD), we developed an LMNA-mutated primate model based on the similarity between the phenotype of primates and humans. We screened out patients with LMD and compared the clinical data of LMD with TTN-mutated and mutation-free dilated cardiomyopathy to obtain the unique phenotype. After establishment of the LMNA...

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PMID: 38559624
DOI: 10.1016/j.jacbts.2023.11.002

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