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Article

DHEA and response to antidepressant treatment: A Mendelian Randomization analysis.

Journal of psychiatric research - 1 May 2024

Souza-Teodoro L H, Davies N M, Warren H R, Andrade L H S G, Carvalho L A

Abstract excerpt

Treatment response is hard to predict and detailed mechanisms unknown. Lower levels of the dehydroepiandrosterone sulphate (DHEA(S)) - a precursor to testosterone and estrogen - have been associated to depression and to response to antidepressant treatment. Previous studies however may have been ridden by confounding and reverse causation. The aim of this study is to evaluate whether higher levels of DHEA(S) are...

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PMID: 38531145
DOI: 10.1016/j.jpsychires.2024.02.049

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