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Article

Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene.

Epigenetics - 1 Dec 2024

Zheng Caiqing, Ma Ling, Song Fan, Tian Li, Cai Wanzhi, Li Hu, Duan Yuange

Abstract excerpt

Although A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by 'epigenetically' regulating proteomic diversity in a temporospatial manner, avoiding the pleiotropic effect of genomic mutations. Recent discoveries on the evolutionary trajectory of Ser>Gly auto-editing site in insect Adar gene demonstrated a selective...

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Identifiers

PMID: 38525798
DOI: 10.1080/15592294.2024.2333665
PMCID: PMC10965108

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