Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders.

doi:10.1016/j.biopsych.2024.03.011

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Article

Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders.

Biological psychiatry - 1 Sept 2024

González-Peñas Javier, Alloza Clara, Brouwer Rachel, Díaz-Caneja Covadonga M, Costas Javier, González-Lois Noemí, Gallego Ana Guil, de Hoyos Lucía, Gurriarán Xaquín, Andreu-Bernabeu Álvaro, Romero-García Rafael, Fañanás Lourdes, Bobes Julio, González-Pinto Ana, Crespo-Facorro Benedicto, Martorell Lourdes, Arrojo Manuel, Vilella Elisabet, Gutiérrez-Zotes Alfonso, Perez-Rando Marta, Moltó María Dolores, Buimer Elizabeth, van Haren Neeltje, Cahn Wiepke, O'Donovan Michael, Kahn René S, Arango Celso, Pol Hilleke Hulshoff, Janssen Joost, Schnack Hugo

Abstract excerpt

BACKGROUND: Schizophrenia is a highly heritable disorder characterized by increased cortical thinning throughout the life span. Studies have reported a shared genetic basis between schizophrenia and cortical thickness. However, no genes whose expression is related to abnormal cortical thinning in schizophrenia have been identified. METHODS: We conducted linear mixed models to estimate the rates of accelerated...

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Identifiers

PMID: 38521159
DOI: 10.1016/j.biopsych.2024.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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