Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency.

doi:10.1038/s41586-024-07213-6

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Article

Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency.

Nature - 1 Apr 2024

Martin Emmanuel, Winter Sarah, Garcin Cécile, Tanita Kay, Hoshino Akihiro, Lenoir Christelle, Fournier Benjamin, Migaud Mélanie, Boutboul David, Simonin Mathieu, Fernandes Alicia, Bastard Paul, Le Voyer Tom, Roupie Anne-Laure, Ben Ahmed Yassine, Leruez-Ville Marianne, Burgard Marianne, Rao Geetha, Ma Cindy S, Masson Cécile, Soudais Claire, Picard Capucine, Bustamante Jacinta, Tangye Stuart G, Cheikh Nathalie, Seppänen Mikko, Puel Anne, Daly Mark, Casanova Jean-Laurent, Neven Bénédicte, Fischer Alain, Latour Sylvain

Abstract excerpt

Epstein-Barr virus (EBV) infection can engender severe B cell lymphoproliferative diseases1,2. The primary infection is often asymptomatic or causes infectious mononucleosis (IM), a self-limiting lymphoproliferative disorder3. Selective vulnerability to EBV has been reported in association with inherited mutations impairing T cell immunity to EBV4. Here we report biallelic loss-of-function variants in IL27RA that...

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Identifiers

PMID: 38509369
DOI: 10.1038/s41586-024-07213-6

Genes

IL27RA
STAT1
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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