Article
Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27.
Haematologica - 1 Mar 2013
Salzer Elisabeth, Daschkey Svenja, Choo Sharon, Gombert Michael, Santos-Valente Elisangela, Ginzel Sebastian, Schwendinger Martina, Haas Oskar A, Fritsch Gerhard, Pickl Winfried F, Förster-Waldl Elisabeth, Borkhardt Arndt, Boztug Kaan, Bienemann Kirsten, Seidel Markus G
Abstract excerpt
CD27, a tumor necrosis factor receptor family member, interacts with CD70 and influences T-, B- and NK-cell functions. Disturbance of this axis impairs immunity and memory generation against viruses including Epstein Barr virus (EBV), influenza, and others. CD27 is commonly used as marker of memory B cells for the classification of B-cell deficiencies including common variable immune deficiency. Flow cytometric...
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