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Two polymorphic cholesterol monohydrate crystal structures form in macrophage culture models of atherosclerosis

2 Jul 2018

Abstract excerpt

The formation of atherosclerotic plaques in the blood vessel walls is the result of LDL particle uptake, and consequently of cholesterol accumulation in macrophage cells. Excess cholesterol accumulation eventually results in cholesterol crystal deposition, the hallmark of mature atheromas. We followed the formation of cholesterol crystals in J774A.1 macrophage cells with time, during accumulation of LDL...

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PMID: 29967179
DOI: 10.1073/pnas.1803119115

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