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Article

Foam cells of the rabbit atherosclerotic plaque arrested in metaphase by colchicine show a macrophage phenotype.

Atherosclerosis - 1 May 1991

Spagnoli L G, Orlandi A, Santeusanio G

Abstract excerpt

Proliferative activity of smooth muscle cells and foam cells characterizes experimental atherosclerotic plaques as they first appear. Immunohistochemical and ultrastructural methods were applied to cells arrested in metaphase by colchicine and the phenotype of cells in mitosis was detected. Most of the metaphase arrested FC found in aortic plaques of cholesterol fed New Zealand rabbits were positive to the...

Topics

Animals
Aorta
Arteriosclerosis
Colchicine
Female
Foam Cells
Immunohistochemistry
Macrophages
Metaphase
Mitosis
Phenotype
Rabbits

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Identifiers

PMID: 1878013
DOI: 10.1016/0021-9150(91)90260-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1878013-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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