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YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions

17 Mar 2024

Abstract excerpt

BACKGROUND: The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). Accumulating evidence suggests a close association between insufficient mitophagy and RTEC senescence. Yeast mitochondrial escape 1-like 1 (YME1L), an inner mitochondrial membrane metalloprotease, maintains mitochondrial integrity. Its functions in DKD remain unclear. Here, we...

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Share to Autophagy in Disease and Therapy
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PMID: 38494498
DOI: 10.1186/s40659-024-00487-0

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