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Article

Mitophagy: Basic Mechanism and Potential Role in Kidney Diseases

1 Jan 2015

Abstract excerpt

BACKGROUND: Mitochondria play fundamental roles in cellular metabolism, signaling, and viability. Disruption of mitochondria not only leads to dysfunction of the organelles but also activates mechanisms of cell injury and death, contributing to the pathogenesis of various diseases. SUMMARY: Removal of damaged mitochondria is therefore crucial for cellular homeostasis and survival. Mitophagy, the selective...

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Share to Autophagy in Disease and Therapy
Share to Chronic Kidney Disease and Diabetes
Share to Dialysis and Renal Disease Management

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27536667
DOI: 10.1159/000381510

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