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Article

Temporospatial hierarchy and allele-specific expression of zygotic genome activation revealed by distant interspecific urochordate hybrids.

Nature communications - 16 Mar 2024

Wei Jiankai, Zhang Wei, Jiang An, Peng Hongzhe, Zhang Quanyong, Li Yuting, Bi Jianqing, Wang Linting, Liu Penghui, Wang Jing, Ge Yonghang, Zhang Liya, Yu Haiyan, Li Lei, Wang Shi, Leng Liang, Chen Kai, Dong Bo

Abstract excerpt

Zygotic genome activation (ZGA) is a universal process in early embryogenesis of metazoan, when the quiescent zygotic nucleus initiates global transcription. However, the mechanisms related to massive genome activation and allele-specific expression (ASE) remain not well understood. Here, we develop hybrids from two deeply diverged (120 Mya) ascidian species to symmetrically document the dynamics of ZGA. We...

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Identifiers

PMID: 38493164
DOI: 10.1038/s41467-024-46780-0
PMCID: PMC10944513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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