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Article

Primary Cutaneous Aspergillosis in a Patient with CARD9 Deficiency and Aspergillus Susceptibility of Card9 Knockout Mice.

Journal of clinical immunology - 1 Feb 2021

Zhang Yi, Huang Chen, Song Yinggai, Ma Yubo, Wan Zhe, Zhu Xuejun, Wang Xiaowen, Li Ruoyu

Abstract excerpt

PURPOSE: We describe a case of primary cutaneous aspergillosis caused by Aspergillus fumigatus, and elucidate the underlying genetic and immunological mechanisms. MATERIALS AND METHODS: Routine clinical and laboratory investigations were performed. Whole-exome sequencing of the patient's DNA suggested the presence of a CARD9 mutation, which was confirmed by Sanger sequencing. Innate and adaptive immunological...

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PMID: 33180249
DOI: 10.1007/s10875-020-00909-0

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