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Role of sex in immune response and epigenetic mechanisms

22 Jan 2024

Abstract excerpt

The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inactivation, mosaicism, skewing, and dimorphism in X chromosome genes and Y chromosome regulatory genes create a sex-based variance in the immune response between males and females. This leads to differential...

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PMID: 38247002
DOI: 10.1186/s13072-024-00525-x

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