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The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas

11 Mar 2024

Abstract excerpt

We identified a progenitor cell population highly enriched in samples from invasive and chemo-resistant carcinomas, characterized by a well-defined multigene signature including APOD, DCN, and LUM. This cell population has previously been labeled as consisting of inflammatory cancer-associated fibroblasts (iCAFs). The same signature characterizes naturally occurring fibro-adipogenic progenitors (FAPs) as well as...

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PMID: 38466528
DOI: 10.1007/s10555-024-10181-y

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