Article
A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region.
Nature communications - 9 Jun 2020
Ngabonziza Jean Claude Semuto, Loiseau Chloé, Marceau Michael, Jouet Agathe, Menardo Fabrizio, Tzfadia Oren, Antoine Rudy, Niyigena Esdras Belamo, Mulders Wim, Fissette Kristina, Diels Maren, Gaudin Cyril, Duthoy Stéphanie, Ssengooba Willy, André Emmanuel, Kaswa Michel K, Habimana Yves Mucyo, Brites Daniela, Affolabi Dissou, Mazarati Jean Baptiste, de Jong Bouke Catherine, Rigouts Leen, Gagneux Sebastien, Meehan Conor Joseph, Supply Philip
Abstract excerpt
The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly...
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