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Generation of heterozygous (MCRIi030-A-1) and homozygous (MCRIi030-A-2) NR2F2/COUP-TFII knockout human iPSC lines.

Stem cell research - 1 Apr 2024

Ferreira Lucas G A, Cabral-da-Silva Mauricio C, Pachernegg Svenja, van den Bergen Jocelyn A, Robevska Gorjana, Vlahos Katerina, Howden Sara E, Ng Elizabeth S, Dias-da-Silva Magnus R, Sinclair Andrew H, Ayers Katie L

Abstract excerpt

The NR2F2 gene encodes the transcription factor COUP-TFII, which is upregulated in embryonic mesoderm. Heterozygous variants in NR2F2 cause a spectrum of congenital anomalies including cardiac and gonadal phenotypes. We generated heterozygous (MCRIi030-A-1) and homozygous (MCRIi030-A-2) NR2F2-knockout induced pluripotent stem cell (iPSC) lines from human fibroblasts using a one-step protocol for CRISPR/Cas9...

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PMID: 38458031
DOI: 10.1016/j.scr.2024.103374

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Generation of heterozygous (MCRIi030-A-1) and homozygous (MCRIi030-A-2) NR2F2/COUP-TFII knockout human iPSC lines.PMID 38458031Read ↗

Evidence for <i>NR2F2</i> /COUP-TFII involvement in human testis developmentSemantic proximity Read ↗

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Evidence for NR2F2/COUP-TFII involvement in human testis development.Semantic proximity Read ↗

Heterozygous rare variants in NR2F2 cause a recognizable multiple congenital anomaly syndrome with developmental delaysSemantic proximity Read ↗

Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children.Semantic proximity Read ↗

COUP-TFII Regulates Human Endometrial Stromal Genes Involved in InflammationSemantic proximity Read ↗

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