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A T cell–based SARS-CoV-2 spike protein vaccine provides protection without antibodies

23 Jan 2024

Abstract excerpt

SARS-CoV-2 spike-based vaccines are used to control the COVID-19 pandemic. However, emerging variants have become resistant to antibody neutralization and further mutations may lead to full resistance. We tested whether T cells alone could provide protection without antibodies. We designed a T cell-based vaccine in which SARS-CoV-2 spike sequences were rearranged and attached to ubiquitin. Immunization of mice...

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PMID: 38456504
DOI: 10.1172/jci.insight.155789

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