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Article

Distinct Molecular and Clinical Features of Specific Variants of KRAS Codon 12 in Pancreatic Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 17 Mar 2025

Ardalan Bach, Ciner Aaron, Baca Yasmine, Hinton Andrew, Darabi Sourat, Kasi Anup, Lou Emil, Azqueta Jose Ignacio, Xiu Joanne, Datta Jashodeep, Shields Anthony F, Aguirre Andrew, Singh Harshabad, Shroff Rachna T, Pishvaian Michael J, Goel Sanjay

Abstract excerpt

PURPOSE: Oncogenic mutations in KRAS have been identified in >85% of pancreatic ductal adenocarcinoma (PDAC) cases, with G12D, G12V, and G12R being the most frequent variants. Using large clinical and genomic databases, this study characterizes prognostic and molecular differences between KRAS variants, focusing on KRASG12D and KRASG12R. EXPERIMENTAL DESIGN: PDAC samples were tested using DNA and RNA sequencing....

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Identifiers

PMID: 39821054
DOI: 10.1158/1078-0432.CCR-24-3149
PMCID: PMC11911800

Genes

KRAS
ARID1A
KMT2D

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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