Article
Mutations of epigenetic modifier genes predict poor outcome in adult acute lymphoblastic leukemia.
Annals of hematology - 1 Sept 2024
Ou Jiawang, Deng Shiyu, Ding Chenhao, Cai Zihong, Chen Junjie, Huang Zicong, Xu Xiuli, Li Jia, Wu Zhengwei, Tang Bingqing, Zhang Ting, Wang Zhixiang, Zhou Ya, Xuan Li, Liu Qifa, Zhou Hongsheng
Abstract excerpt
Epigenetic modifier (EM) genes play important roles in the occurrence and progression of acute lymphoblastic leukemia (ALL). However, the prognostic significance of EM mutations in ALL has not yet been thoroughly investigated. This retrospective study included 205 adult patients with ALL engaged in a pediatric-type regimen. Based on targeted next-generation sequencing, they were divided into EM mutation group...
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