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Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

2024-10-22

Abstract excerpt

<title>Abstract</title> <p><italic>Background: </italic>Concerning the dismal prognosis of chemoresistant patients with epithelial ovarian carcinoma (EOC), we aimed to validate the findings of a previous whole exome sequencing study on 50 patients using an orthogonal Sanger sequencing method on the same patients and a separate set of 127 EOC patients (N=177). <italic>Methods:</italic> We focused on <italic>TP53</...

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Literature Corpus work
0ff2abef-772c-5d67-ad86-f7ee5593996a
DOI
10.21203/rs.3.rs-5224537/v1
Open publication

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Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patientsDOI 10.21203/rs.3.rs-5224537/v1
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