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Article

Effects of Xylanase A double mutation on substrate specificity and structural dynamics.

Journal of structural biology - 1 Jun 2024

MacDonald Meagan E, Wells Nicholas G M, Hassan Bakar A, Dudley Joshua A, Walters Kylie J, Korzhnev Dmitry M, Aramini James M, Smith Colin A

Abstract excerpt

While protein activity is traditionally studied with a major focus on the active site, the activity of enzymes has been hypothesized to be linked to the flexibility of adjacent regions, warranting more exploration into how the dynamics in these regions affects catalytic turnover. One such enzyme is Xylanase A (XylA), which cleaves hemicellulose xylan polymers by hydrolysis at internal β-1,4-xylosidic linkages. It...

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Identifiers

PMID: 38438058
DOI: 10.1016/j.jsb.2024.108082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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