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Article

Exploring genetic associations of Crohn's disease and ulcerative colitis with extraintestinal cancers in European and East Asian populations.

Frontiers in immunology - 1 Jan 2024

Yu Chengdong, Xu Jiawei, Xu Siyi, Tang Lei, Han Qinyuan, Zeng Xiaoqiang, Huang Yanxiao, Yu Tenghua, Sun Zhengkui

Abstract excerpt

Background: Previous studies have reported associations of Crohn's disease (CD) and ulcerative colitis (UC) with the risks of extraintestinal cancers, but the causality remains unclear. Methods: Using genetic variations robustly associated with CD and UC extracted from genome-wide association studies (GWAS) as instrumental variables. Nine types of extraintestinal cancers of European and Asian populations were...

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Identifiers

PMID: 38404590
DOI: 10.3389/fimmu.2024.1339207
PMCID: PMC10885353

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