Global and regional genetic association analysis of ulcerative colitis and type 2 diabetes mellitus and causal validation analysis of two-sample two-way Mendelian randomization.

Abstract excerpt

Background: Clinical co-occurrence of UC (Ulcerative Colitis) and T2DM (Type 2 Diabetes Mellitus) is observed. The aim of this study is to investigate the potential causal relationship between Ulcerative Colitis (UC) and Type 2 Diabetes Mellitus (T2DM) using LDSC and LAVA analysis, followed by genetic verification through TSMR, providing insights for clinical prevention and treatment. Methods: Genetic loci...

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• Colitis, Ulcerative
• Diabetes Mellitus, Type 2
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mendelian Randomization Analysis