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Article

Somatic CAG Repeat Stability in a Transgenic Sheep Model of Huntington's Disease.

Journal of Huntington's disease - 1 Jan 2024

Handley Renee R, Reid Suzanne J, Burch Zoe, Jacobsen Jessie C, Gillis Tammy, Correia Kevin, Rudiger Skye R, McLaughlin Clive J, Bawden C Simon, MacDonald Marcy E, Wheeler Vanessa C, Snell Russell G

Abstract excerpt

Somatic instability of the huntingtin (HTT) CAG repeat mutation modifies age-at-onset of Huntington's disease (HD). Understanding the mechanism and pathogenic consequences of instability may reveal therapeutic targets. Using small-pool PCR we analyzed CAG instability in the OVT73 sheep model which expresses a full-length human cDNA HTT transgene. Analyses of five- and ten-year old sheep revealed the transgene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38393920
DOI: 10.3233/JHD-231516
PMCID: PMC11091634

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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