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Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

22 Feb 2024

Abstract excerpt

Senolytics, small molecules targeting cellular senescence, have emerged as potential therapeutics to enhance health span. However, their impact on epigenetic age remains unstudied. This study aimed to assess the effects of Dasatinib and Quercetin (DQ) senolytic treatment on DNA methylation (DNAm), epigenetic age, and immune cell subsets. In a Phase I pilot study, 19 participants received DQ for 6 months, with...

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Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

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PMID: 38393697
DOI: 10.18632/aging.205581

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