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Article

Mutant Tbl1x male mice have a short life span and do not breed: unexpected findings.

Journal of molecular endocrinology - 1 Jul 2024

Hu Yalan, Codner Gemma F, Stewart Michelle, La Fleur Susanne E, van Trotsenburg Paul A S, Fliers Eric, Hennekam Raoul C, Boelen Anita

Abstract excerpt

Humans with the mutation Y509C in transducin beta like 1 X-linked (TBL1X HGNC ID HGNC:11585) have been reported to present with the combination of central congenital hypothyroidism and impaired hearing. TBL1X belongs to the WD40 repeat-containing protein family, is part of NCoR and SMRT corepressor complexes, and thereby involved in thyroid hormone signaling. In order to investigate the effects of the Y509C...

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Identifiers

PMID: 38381448
DOI: 10.1530/JME-23-0116

Genes

TBL1X

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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