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Mechanistic regulation of HERV activation in tumors and implications for translational research in oncology

6 Feb 2024

Abstract excerpt

Transcription of distinct loci of human endogenous retroviruses (HERVs) and in some cases, translation of these transcripts have been consistently observed in many types of cancer. It is still debated whether HERV activation serves as a trigger for carcinogenesis or rather occurs as a consequence of epigenetic alterations and other molecular sequelae that characterize cellular transformation. Here we review the...

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PMID: 38379771
DOI: 10.3389/fcimb.2024.1358470

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