Article
Somatic mutations in solid tumors: a spectrum at the service of diagnostic armamentarium or an indecipherable puzzle? The morphological eyes looking for BRAF and somatic molecular detections on cyto-histological samples.
Oncotarget - 10 Jan 2017
Rossi Esther Diana, Martini Maurizio, Bizzarro Tommaso, Schmitt Fernando, Longatto-Filho Adhemar, Larocca Luigi Maria
Abstract excerpt
This review article deals with the analysis and the detection of the morphological features associated with somatic mutations, mostly BRAFV600E mutation, on both cytological and histological samples of carcinomas. Few authors demonstrated that some architectural and specific cellular findings (i.e. polygonal eosinophilic cells defined as "plump cells" and sickle-shaped nuclei) are able to predict BRAF V600E...
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