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Pigs in Transplantation Research and Their Potential as Sources of Organs in Clinical Xenotransplantation

16 Feb 2024

Abstract excerpt

The pig has long been used as a research animal and has now gained importance as a potential source of organs for clinical xenotransplantation. When an organ from a wild-type (i. e., genetically unmodified) pig is transplanted into an immunosuppressed nonhuman primate, a vigorous host immune response causes hyperacute rejection (within minutes or hours). This response has been largely overcome by 1) extensive...

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PMID: 38359908
DOI: 10.30802/aalas-cm-23-000030

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