Article
Establishment of induced pluripotent stem cell lines derived from Parkinson's disease Mexican patients: A sporadic (UNAMi002-A) and a familial (UNAMi003-A) case carrying a mutation in PINK1.
Stem cell research - 1 Apr 2024
Flores-Ponce Xóchitl, López-Ornelas Adolfo, Escobedo-Avila Itzel, Rodríguez-Violante Mayela, Dávila-Ortiz de Montellano David, Cervantes-Arriaga Amín, Monroy-Jaramillo Nancy, Campos-Romo Aurelio, Velasco Iván
Abstract excerpt
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a prominent reduction of striatal dopamine levels leading to motor alterations. The mechanisms underlying neurodegeneration in PD remain unknown. Here, we generated an induced pluripotent stem cell line from dermal fibroblasts of a Mexican patient diagnosed with...
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