Article
Increased burden of rare protein-truncating variants in constrained, brain-specific and synaptic genes in extremely impulsively violent males with antisocial personality disorder.
Genes, brain, and behavior - 1 Feb 2024
Mušálková Dita, Přistoupilová Anna, Jedličková Ivana, Hartmannová Hana, Trešlová Helena, Nosková Lenka, Hodaňová Kateřina, Bittmanová Petra, Stránecký Viktor, Jiřička Václav, Langmajerová Michaela, Woodbury-Smith Marc, Zarrei Mehdi, Trost Brett, Scherer Stephen W, Bleyer Anthony J, Vevera Jan, Kmoch Stanislav
Abstract excerpt
The genetic correlates of extreme impulsive violence are poorly understood, and there have been few studies that have characterized a large group of affected individuals both clinically and genetically. We performed whole exome sequencing (WES) in 290 males with the life-course-persistent, extremely impulsively violent form of antisocial personality disorder (APD) and analyzed the spectrum of rare...
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