Article
Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment.
The American journal of psychiatry - 1 Jan 2026
Mallard Travis T, Tubbs Justin D, Jennings Mariela, Zhang Yingzhe, Gustavson Daniel E, Grotzinger Andrew D, Westwater Margaret L, Williams Camille M, Fortgang Rebecca G, Elson Sarah L, Fontanillas Pierre, Davis Lea K, Raznahan Armin, Tucker-Drob Elliot M, Choi Karmel W, Ge Tian, Smoller Jordan W, Palmer Abraham A, Sanchez-Roige Sandra
Abstract excerpt
OBJECTIVE: Impulsivity is a complex mental construct and a core feature of many psychiatric and neurological conditions. The aim of this study was to formally model the genetic architecture of eight impulsive traits, identifying their shared and distinct genetic influences, to advance our biological understanding of impulsivity. METHODS: The authors analyzed genetic data from up to 133,517 individuals using novel...
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