Article
Parkin mRNA Expression Levels in Peripheral Blood Mononuclear Cells in Parkin-Related Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2024
Papagiannakis Nikolaos, Liu Hui, Koros Christos, Simitsi Athina-Maria, Stamelou Maria, Maniati Matina, Buena-Atienza Elena, Kartanou Chrysoula, Karadima Georgia, Makrythanasis Periklis, Vatsellas Giannis, Valente Enza Maria, Gasser Thomas, Stefanis Leonidas
Abstract excerpt
INTRODUCTION: Pathogenic variants in parkin (PRKN gene) are the second most prevalent known monogenic cause of Parkinson's disease (PD). How monoallelic or biallelic pathogenic variants in the PRKN gene may affect its transcription in patient-derived biological material has not been systematically studied. METHODS: PRKN mRNA expression levels were measured with real-time polymerase chain reaction (RT-PCR) in...
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