Article

Transcriptional changes in the peripheral blood of at-risk individuals without clinical manifestation of Parkinson’s Disease

2026-04-07

Abstract excerpt

<title>Abstract</title> We have previously reported a global reduction of circular RNA (circRNA) levels in the peripheral blood of patients with early-stage idiopathic PD (iPD). This reduction was accompanied by increased expression of genes involved in innate immune response to double-stranded RNA. (dsRNA-IIR). Here, we extend these findings using whole-blood RNA sequencing data from 916 participants in the P...

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Literature Corpus work: 1c09f047-0323-53d8-adb4-029f038a2759
DOI: 10.21203/rs.3.rs-9178344/v1

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