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Article

SLC39A5 dysfunction impairs extracellular matrix synthesis in high myopia pathogenesis.

Journal of cellular and molecular medicine - 1 Sept 2021

Dong Shanshan, Tian Qi, Zhu Tengfei, Wang Kangli, Lei Ganting, Liu Yanling, Xiong Haofeng, Shen Lu, Wang Meng, Zhao Rongjuan, Wu Huidan, Li Bin, Zhang Qiumeng, Yao Yujun, Guo Hui, Xia Kun, Xia Lu, Hu Zhengmao

Abstract excerpt

High myopia is one of the leading causes of visual impairment worldwide with high heritability. We have previously identified the genetic contribution of SLC39A5 to nonsyndromic high myopia and demonstrated that disease-related mutations of SLC39A5 dysregulate the TGF-β pathway. In this study, the mechanisms underlying SLC39A5 involvement in the pathogenesis of high myopia are determined. We observed the...

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PMID: 34302427
DOI: 10.1111/jcmm.16803
PMCID: PMC8419198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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