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Article

The Relevance of Integrating CYP2C19 Phenoconversion Effects into Clinical Pharmacogenetics.

Pharmacopsychiatry - 1 Mar 2024

Scherf-Clavel Maike, Weber Heike, Unterecker Stefan, Frantz Amelie, Eckert Andreas, Reif Andreas, Deckert Jürgen, Hahn Martina

Abstract excerpt

INTRODUCTION: CYP2D6 and CYP2C19 functional status as defined by genotype is modulated by phenoconversion (PC) due to pharmacokinetic interactions. As of today, there is no data on the effect size of PC for CYP2C19 functional status. The primary aim of this study was to investigate the impact of PC on CYP2C19 functional status. METHODS: Two patient cohorts (total n=316; 44.2±15.4 years) were investigated for the...

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Identifiers

PMID: 38354747
DOI: 10.1055/a-2248-6924
PMCID: PMC10948286

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